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Medical Marijuana and Crohn's Disease


There is now extensive evidence from patients with Crohn's disease and other painful GI disorders that cannabis eases cramping and helps modulate diarrhea, constipation and acid reflux.

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"Cannabis has a long documented history of use in treating GI distress, going back more than a century in western medicine, and far longer in the east... Cannabis and new cannabinoid drugs are attractive for GI treatment because they can address a number of symptoms at once with minimal side effects."

-From Americans for Safe Access brochure Gastrointestinal Disorders and Medical Marijuana

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Published Research Articles

Cannabinoid CB₁-reception mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation
Izzo, Angelo A., et al. (2001) British Journal of Pharmacology. 134: 563-570

Delta-9-tetrahydrocannabinol as an antiemetic
Anderson PO, McGuire GG. (1981) American Society of Health-System Pharmacists. 38: 639-46.

The Gastrointestinal Pharmacology of Cannabinoids
Izzo, Angelo A., et al. (2001) Current Opinion in Pharmacology. 6: 597-603

Clinical Endocannabinoid Deficiency (CECD): Can this concept explain thereputic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
Russo, Ethan B. (2004) Neuropharmacology Letters. 25: 31-39

Cannabinoids for Gastrointestinal Diseases: Potential Therapeutic Applications
Izzo, Angelo A., et al. (2003) Expert Opinion on Investigational Drugs. 12: 39-49.

Evolving Concepts in Functional Gastrointestinal Disorders: Promising Directions for Novel Pharmaceutical Treatments
Hunt, Richard H. et al. (2002) Best Practice & Research Clinical Gastroenterology. 16: 869-883.